After discovering that his late father has gone through most of the family fortune, Tod Stiles hits the title trans-America highway in his Corvette in search of adventure with friend Buz Murdock, a survivor of New York's mean streets. The two work odd jobs as they meet and interact with colorful characters and find themselves plunged into one situation after another, some of them romantic, some of them very dangerous. Later, Linc Case, a Vietnam war hero trying to find himself, takes over as Tod's travel companion.

在父亲的强力干预下，知名心理学家小梁被迫接手了家族的当铺生意。从此，小梁用新奇怪异的方式开启了自己的“救赎”之路。三年来，第66号当铺里怪事不断，各种怪人也接踵而至。心理极度矛盾的怪人老齐也慕名而来，得知自己所带物品一文不值后，老齐向小梁讲述了自己的故事，在老齐的故事里，小梁感受到了从未有过的恐惧，甚至悲凉。面对身心俱弱的老齐，小梁用精辟的心理学知识对老齐展开了特殊救助。

“大阴人”（The Big Yin）化身《逍遥骑士》（Easy Rider）中的主角，追寻一生的梦想，踏上了从芝加哥到圣莫尼卡这段长达2488英里的标志性旅程。凭借其无与伦比的讲故事能力，他将美国历史上的重大和细微时刻都鲜活地展现出来：既有改变世界的大事件，也有诙谐的小插曲。

在调查过程中，一名记者在圣保罗郊区发现越来越多无辜的警察受害者。远离聚光灯的是，针对黑人和贫穷青年的过度暴力。

现代社畜唐建国穿越西游，成为 66 号备胎取经人。各路机缘早已被其他取经人抢占，他一无所有，只拥有消耗功德兑换物资的投喂系统。初至双叉岭便险些命丧妖口，他透支功德变出烤肉，收服吃货虎大、熊二充当保镖。组建起画风怪异的取经小队，一人两妖踏上充满爆笑危机的荒诞西行之路。

66 tells the story of an assassin-for-hire, who is hired to kill a police informant, but instead steals the money and runs, igniting the spark that leads a criminal organization to go to war with itself.

Documentary exploring the key events of 1966, a period when British pop music, fashion and sport was making waves across the globe, but when the nation's upbeat mood was undercut by darker sensibilities.