Brain chemistry research has produced a drug - Nirvana - that can wipe out addiction and mental illness by stimulating pleasure centers in the brain and flooding the brain with endorphins. PsyMax Labs is about to release Nirvana, but suddenly something goes badly wrong. Nirvana causes drastic genetic changes, switching on dormant genes to produce BRAINIAC, a creature whose need for the brain's pleasure chemicals causes it to begin eating human brains.

A spin-off of the show Brainiac: Science Abuse concentrating on historical subjects.

Live parody of the popular science entertainment TV show Brainiac: Science Abuse.

制作公司：华纳兄弟影片公司 [美国] 发行公司：华纳家庭视频公司 [美国] 超人越来越受群众的爱戴，而老对手卢瑟也更加怨恨他了。为了打败超人，卢瑟研究了一种新型武器，还特意注入一种特制的氪化合物，将Brainiac装备得无坚不摧。因女友路易斯受伤，超人必须到神秘的幻影世界去寻找解药。Brianiac以为超人将有去无回，于是背叛了卢瑟，开始随心所 欲在城市里到处肆虐，而超人必须赶在他毁灭地球之前阻止他。 打斗很爽啊，不过超人似乎完全不在意战斗时对大都会造成的损害，恐怕有一半城市都被他们拆了...对Bruce Timm的DCAU系列来说，JLU才是它的终结，给了这个系列一个完满的句号——或者说通向更多未尽战斗的省略号。而不是这部骗取了所有fans感情的所谓《Superma n: Brainiac Attacks》。在STAS完结近10年的时候，华纳放弃JLU的DTV不做，特意出Superman，当然是司马昭之心路人皆知的，百度影音摆明了是要搭超人5电影的车。由于要赶电影的档极影影院期，这部片子的草率也就完全是情理之中了。只可怜翘首以待的忠实fans们，他们对DCAU实在抱了无比的信心——而这部片就毫不留情的将他们的期待与信任，连同Bruce Timm十余年来的苦心经营一举粉碎。

In 1661 Mexico, the Baron Vitelius of Astara is sentenced to be burned alive by the Holy Inquisition of Mexico for witchcraft, necromancy, and other crimes. As he dies, the Baron swears vengeance against the descendants of the Inquisitors. 300 years later, a comet that was passing overhead on the night of the Baron’s execution returns to earth, bringing with it the Baron in the form of a horrible, brain-eating monster that terrorizes the Inquisitor’s descendants.