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In a small town in Chile, women and young children have been mysteriously vanishing. Suspicion falls on the local mayor, Dupui, and a shadowy figure called Dr. Werner. Dupui keeps tight control over the town through a gang called the Yellow Jackets, hand-picked by Dupui and under his control through the use of a drug which he calls 'Possession.' As the forces of good close in on the mayor and his evil gang, events start to spiral out of control and an ancient force of evil is released.

瑞安·斯通博士（桑德拉·布洛克饰）是一个天资聪颖的医药工程师。在第一次航天飞行任务中，她与经验丰富的宇航员麦特·科沃斯基（乔治·克鲁尼饰）一同被任命。但在看似常规的任务中，灾难发生了，两人孤零零地处在外太空……