The story is about the inhabitants of the fictional town of Hamburg, locked in a castle in quarantine. William, the Messenger who brought the news of the plague, is also locked up in the castle.

Barney just wants to hibernate for the winter, but his nephew, just in from the North Pole, has other plans.

Fast-talking Latino con artist Pestario "Pest" Vargas is the target of Scottish mobsters to whom he owes a considerable debt. Willing to do anything to raise money and avoid severe injury or death, Vargas agrees to a very unusual job -- he will be transported to a remote island and hunted by Gustav Shank, a racist German executive. If he can survive a full day and night, Vargas gets $50,000 and will be set free. Is he wily enough to elude Shank?

Naive country girl Jigs Blodgett makes friends with Gene Giles, the nephew of a wealthy judge. Shady John Harland is courting the judge's daughter Blanche because of her father's money and position. To amuse herself, Blanche invites Jigs to a party with her "sophiscated" friends, intending to humiliate and embarrass Jigs. Things don't quite go the way Blanche planned.

Doc, the freeloading cat, is painting a portrait of a ballet dancer using as a model homely, punch-drunk bulldog Champ, wearing an abbreviated skirt. Two alley cats, looking over a fence, see Champ in his attire and begin razzing him. Champ does a slow turn and starts after the cats and, in no time, the studio is a shambles. Doc sees an announcement of a dog show, the winner of which receives a $50,000 prize and a banquet. Desperately in need of money, Doc gets the idea of entering Champ in the upcoming show and begins grooming him. Doc gives Champ a bath, lessons in proper speech, walking with books balanced on head, and the proper attire.

Barney is settling in for his hibernation when a squirrel spots his bedtime snack: a bowl of walnuts. The squirrel sneaks in and wakes Barney up. Barney chases out the squirrel, who proceeds to drop first the nut, then himself, down Barney's noisy tin roof.

A slapstick comedy short with Neely Edwards.

Sylvester Cat must catch mice or lose his happy home. When he can't find a mouse inside, he searches out of doors and comes upon one meek, little mouse who agrees under duress to be Sylvester's one rodent to catch and rough up again and again in front of his masters. But it isn't long before the mouse realizes Sylvester needs him alive and decides to stop being Sylvester's stooge.

For no apparent reason, Porky Pig is awarded the grand prize of the "What's the Name of Your Name" game show. Unfortunately, the prize is Daffy Duck, whose tactless and rude visit gets him tossed out Porky's house by the irate pig. Insulted, Daffy decides to get back at Porky by pretending to have dissociative identity disorder, becoming a hideous monster whenever he's treated unpleasantly. When Porky eventually finds out he's been had, he decides to give the duck a taste of his own medicine.

The cartoon follows Scrappy as he tries to get rid of his baby brother, Oopy, so he can go on a fishing trip with his dog. The more Oopy insists on tagging along, the more violent Scrappy turns against him.