Severino returns to his tribe - the Manzeneros, who live on the edge of the Argentinian Andes - after being gone for 10 years. He has returned to take his younger brother back with him up north, but encounters a host of problems in his home village instead. His father Raymundo, who was on the trail of a gang of white bandits who were stealing cattle from both Indians and settlers, has been recently found dead. A sheep-ranching company turns out to be behind this criminal activity. The company wants to drive the Indians and settlers off the fertile land so that they can purchase it for nothing. Severino decides to remain in his home village to defend it from them, but also because he has fallen in love with Maruja, the granddaughter of the old chief Nicolas, who is filled with hatred against the white settlers. True to form, Nicolas calls for war against the settlers. Severino tries to mediate between the hostile parties.

The series will revolve around the true story of the Catholic priest Severino Mallari, who murdered 57 people during the Spanish colonial era in the Philippines; predating the infamous Jack the Ripper. Severino, who was convinced that a curse afflicted his mother, believed that he could cure her condition through these killings. Trillo takes on the role of Severino, while De Leon portrays his mother.

Rejane returns to her hometown, Paraíso, in search of answers to her brother's murder.