The roaming ghost of punk-funk musician and notorious wild man Rick James possesses the bodies of queer women and makes them get super-freaky with one another.

Evil, power-hungry cult leader Moby wants to obtain the original formula to LSD which is inside of JFK's brain. Miley Cyrus has this magic brain but it's stolen by a blonde superfreak, so Cyrus enlists Santa and a lesbian Bigfoot to hunt down this blonde superfreak. In the end, the blonde superfreak kills them both and a baby mole ends up with the brain.