晋灵公（梁锐）宠信奸佞屠岸贾（李英），时边关告急，相国赵盾（井淼）启奏；晋灵公反受屠岸贾挑拨，下令斩杀赵家三百余口，幸忠臣程婴（严俊）抱赵盾幼孙赵武出走。屠下令杀全国男婴以断后患，程不惜以己子代替。赵武（凌波）长大后，程藉「雪冤图」详述杀其一家三百余口之仇人乃屠岸贾，更安排他与母亲庄姬（李丽华）相认，再设计请屠岸贾尝野味，让赵武手刃大仇人。程婴功成退隐，邻人感其忠烈，赠匾「万古流芳」。

In 1860 Paris, chemist Louis Pasteur is considered a quack within the medical community for advocating that doctors and surgeons wash their hands and boil their instruments to destroy microbes that can kill their patients. He came across this belief when discovering microscopic organisms in sour wine which could be killed if heated sufficiently. The belief among the scientific community at large is that the organisms are the result of disease and not the cause. This belief is despite the fact that 30% of women die in childbirth due to childbed disease, accounting for 20,000 annual deaths in Paris alone. The debate takes Pasteur all the way to a meeting with Emperor Napoleon III and his physician, Dr. Charbonnet, who is one of the leading opponents of Pasteur. Several years later, France is a republic and much of Pasteur's reputation changes as a government sanctioned experiment with anthrax and sheep shows that a vaccine created by Pasteur proves effective. As Pasteur begins work on finding the cause and a cure for rabies, which proves a more difficult challenge, he still has his detractors, including Dr. Charbonnet. This continuing debate brings about his biggest challenge: proving that microbes are the cause of all disease. Through it all, he is supported not only by his family, but Dr. Jean Martel, who was once a junior physician in the emperor's court and a physician within the republic's government, but who now works with Pasteur and is his son-in-law. But an act of bravado by Charbonnet may ultimately prove to be the breakthrough for which Pasteur is looking. Moving the experimental treatments from animals to humans proves a bigger obstacle, as is Charbonnet's need to win at all cost in the court of public opinion.

1870年，一个叫奇普斯的年轻人被英国布鲁菲学校聘请为教员。由于缺乏教学经验，学生们都不喜欢他。20年过去了，奇普斯仍不受学生欢迎。休假时奇普斯到奥地利旅游，在那里，他认识了温柔而通情达理的凯蒂，恋爱中的奇普斯懂得了如何同学生相处，很快就融入到了学生中间，当上了学监，然后又是校长。但这时，凯蒂却因难产死去，奇普斯悲痛欲绝。新校长到任后，由于在许多问题上存在分歧，协调无果，奇普斯提出了退休的请求，但招致伦敦各界的反对，学校被迫让奇普斯5年后再退休。第一次世界大战爆发后，奇普斯继续留校教书，在战争结束后退休，结束了他默默无闻却桃李满天下的一生。

当一场前所未有的大灾难导致日本大撤离时，Lyra陷入了她的回忆之中。Rey是谁，那个她跨越国度追随的迷人女孩？为什么她会痴迷于一万年前被诸神惩罚的文明—亚特兰蒂斯神话？最重要的是：为什么她竟突然消失了？

叶枫身为长生之人，一直隐藏身份，也一手创建世间最大组织往生殿，却被手下所害，这一世重出江湖，目的便是为了揪出陷害自己之人，保护这一世的家人，踏平所有不服！

叶凡本是九天之上的天帝，击败征服九界的魔头后神魂受损，疗伤时遭挚爱楚嫣然偷袭，被夺走天帝之心，楚嫣然借此登基为天枢女帝。叶凡机缘重生为叶家少主，初期因修为未复被视为废柴，受尽欺凌。96 集剧情里，他逐步觉醒天帝记忆与力量，一路横扫仇敌、揭露楚嫣然的阴谋，在历经宗门大战、秘境探险、天道试炼后，不仅报了前世血仇，更重塑天帝之威，最终打破天道束缚，重登天帝宝座，守护三界安宁。

吴渊遭人陷害入狱，狱中意外习得绝世功法，成为威震天下的万古帝君。出狱后他隐去帝尊身份，只想回归家庭与妻子楚兰团聚，却遭楚家全员冷眼羞辱。妻子楚兰嫌贫爱富，转投白鹰国上将之子王邵恒怀抱，当众提出离婚。吴渊忍无可忍，逐步展露实力，以绝对权势打脸王邵恒与势利楚家。他揭露王家荣耀皆为自己昔日所赐，以帝君之威震慑全场。

叶辰是龙国冥王，在冥山上修行三年，要下山复仇，一众大佬阻拦，龙国两大战神亲临。龙家少主龙夕雪到来，拿出婚约，愿意委身于男主，被男主拒绝。落地江北机场，修罗军指挥使落羽亲自迎接，告知沈芷瑜婚礼的事情。落羽告知叶辰，在他消失这几年，曾经跟着他的小姑娘宁馨如今情况很不好……

蓝星青年林枫穿越至玄天界，绑定万古宗门系统，成为太玄宗初代老祖。系统赋予他特殊力量，只要太玄宗存续，他便拥有无敌修为。林枫亲手建立宗门，横扫八方强敌，镇压妖族，平定黑暗禁区，将动荡东域带入万载太平盛世。

震万古的女帝冲破桎梏归来，看见亲人常年遭受世家势力刁难打压，当即挺身而出。抬手击溃强敌，强势碾压一众宗门大族，立下盟约定下域内秩序。悉心栽培后辈，令晚辈个个崭露头角。待红尘因果了结，她踏向更高境界，家族灯火代代相传，绵延万载。