苏皓自幼跟随师父隐居深山，习得一身精湛医术与强悍武学。遵照师命，他携带婚书下山前往金陵履行婚约，不曾想恰逢薛家深陷婚约风波，机缘之下结识温婉坚韧的薛柔。薛家企业遭遇危机，家族内部矛盾不断，家中老爷子重病缠身，重重困境接踵而至。苏皓与薛柔一路相互扶持、共渡难关，从结伴同行慢慢走向彼此信赖。随着相处渐深，尘封多年的薛家旧闻缓缓显露，师父古三通的过往谜团也浮出水面。昔日不谙世事的山中少年苏皓，正式卷入金陵各方势力纷争，踏上守护挚爱、探寻陈年真相的风云之路。

云霄山传人林枫学成下山，初入云城便救下受扰的苏晴，又医好苏父，却因此卷入周家吞并苏氏的阴谋。他接连周旋于各路对手，破解层层圈套，循旧线追查师门往事，救出被困同门。终以德报怨，借医术消解世家积怨，守住医者本心，觅得宿命知己，开启都市行医新篇。

天医岛主云轩奉师命下山，携玉佩与沈氏总裁沈如玉定下名义婚约。起初受尽轻视，旧婚约柳芊芊退婚。他凭超凡医术屡救众人，折服国医刘一手，化解沈家危机，更发现张氏售卖含毒护肤品，背后竟有天医叛徒作祟。发布会在即，云轩当众揭穿阴谋，叛徒终被战神魏无道拿下。沈如玉、柳芊芊追悔莫及，云轩心怀仁善，以一身本领守护东海百姓。

青云山道士秋辰风下山赴婚约，遭张家悔婚羞辱撕毁婚书。偶遇侦探刘依琳，入职侦探所与其同居。秋辰风凭医武天赋屡破奇案，震慑武道世家、挫败外敌，结识各方武道前辈，查清邪修案件，调解古武家族纷争，终向刘依琳求婚，圆满相守。

凌峰奉母命下山寻姻缘，凭借超凡武力与天策斗数，救下遭绑架的叶家小姐叶灵蔓，认定其为娃娃亲妻子。期间，凌峰屡破奇案、医治疑难杂症，打脸嚣张反派，化解龙家、李家等家族的阴谋算计，在都市中一路逆袭，收获爱情与尊崇，开启宠妻人生。

Dr. Martin Arrowsmith aspires to become a medical research scientist. When he impulsively marries nurse Leora Tozer, he instead decides to open a country medical practice in South Dakota to support his wife better than he could as a laboratory assistant. After a few years of working in his medical practice, Arrowsmith believes that his intuitions are not that well-suited to the job as compared to research. He takes up the offer of Dr. Max Gottlieb, his professor and mentor at Winnemac College, for a research position at the McGurk Institute in New York City. After years of research, Arrowsmith stumbles across a discovery, its practical uses he is initially unsure. When a case of bubonic plague hits an island in the West Indies, respected Swedish scientist Dr. Gustav Sondelius believes that Arrowsmith's discovery could be used as a serum to kill the plague. Despite the personal risk, Arrowsmith travels to the West Indies to see if the serum does indeed work. The serum being untested, Arrowsmith must make the difficult decisions between short term human sacrifices versus the long term benefit to mankind, and between the goals of the institute versus his own ideals. Through it all, Arrowsmith tries to protect Leora from the dangers he faces, she who stands steadfastly by her husband.

绝世神医陈凡奉师命下山，履行一桩救命婚约。他的未婚妻林清雪身负奇毒、惨遭家族迫害。陈凡强势入世，为妻治病、为妻正名、为妻复仇！他医术通神，武道超凡，在都市中掀起惊天波澜，让所有欺辱过他们的人，都付出惨痛代价！

陆准魂穿大雍废物嫡子，遭继母逼迫入赘武家。婚礼上他踢翻火盆当众叫板，与“病丑”武朝朝联手揭穿家族隐秘。凭现代智谋，他替妻母夺权益，交好县令、结盟朱宜之、入股山寨、揽武家产业，终获封永宁县子，扫平敌手，闯出安稳前程。

在那云雾缭绕、与世隔绝的深山之中，有一位神秘莫测的“狂医”。自幼被隐世神医收养，在师父的悉心教导下，钻研古今中外的医学典籍，苦练各种奇经八脉的针灸之法，掌握了无数失传已久的治病绝技。

十六岁生辰那日，张佗华负起雕花木药箱，在药皇的目送中踏碎晨雾下山。他腰间悬着师父所赠的羊脂玉药锄，衣袋里装着亲手绘制的《百毒图谱》，却不知在山脚下的杏林渡口，一位面纱半掩的少女正握着染血的绢帕，在晨风中轻咳。那抹嫣红落在他新采的紫花地丁上，恰似命中注定的朱砂痣。