2013年2月21日，居住在洛杉矶的美国演员萨曼莎（Samantha）收到了一条通过脸书发来的消息，这条消息将彻底改变她的生活。消息来自居住在伦敦的法国时尚设计专业学生阿娜伊斯（Anaïs）。阿娜伊斯的朋友们在YouTube上看到了一个有萨曼莎出镜的视频。她们立刻被萨曼莎和阿娜伊斯惊人相似的外貌所震撼。经过几次简单的谷歌搜索……

On February 21, 2013, Samantha, an American actor living in Los Angeles, received a message via Facebook that would drastically change her life. It was from Anaïs, a French fashion design student living in London. Anaïs' friends viewed a video on YouTube featuring Samantha. They were immediately blown away by the identical appearance of Samantha & Anaïs. After a few light Google stalking sessions, Anaïs & her friends discovered that both girls were born on November 19, 1987 and adopted shortly after. Anaïs knew immediately that it was possible for Samantha to be her biological twin sister and reached out to her through Twitter & Facebook. This sparked the beginning of the journey for Samantha and Anaïs.

As little girls, twin sisters Rianne and Juliette were inseparable, but now that they’re adults, they couldn’t be more different. Rianne takes care of her sick father and his snack bar at home in Rotterdam, while Juliette leads an unfettered life of luxury in Amsterdam. And where Rianne’s passion for collecting is getting more and more out of hand, Juliette is successful as a professional organizer. When father Cor dies, they both do not trust the other to properly carry out his last wish to scatter his ashes on the Spanish coast. The sisters who have grown apart are forced to go on a road trip together.

双胞胎姐妹命运迥异，一场婚礼揭开惊天阴谋。沈梦为查明姐姐离奇死亡真相，毅然化身亡姐潜入豪门秦家。她与英俊多金却心怀鬼胎的丈夫秦亦风周旋，面对步步紧逼的家族成员，沈梦如履薄冰。随着调查深入，她逐渐发现每个人都藏有不可告人的秘密。她能否在这场危机四伏的复仇之路上全身而退？

苏念和苏婉是双胞胎姐妹，长久承受父母偏心以及妹妹欺压。十八岁生辰，她被污蔑并非苏家骨肉，在家中如同佣人，最终惨遭驱逐暗算。深陷绝境的她得到援手，凭着顽强努力逆风翻盘，走出伤痛，收获事业与美满家庭。

林晚禾与妹妹林晓芙双双重生。前世惨死的林晚禾回到父母刚去世时，面对街道办介绍对象，她识破妹妹也想重生的意图，主动放弃教师丈夫，选择前世被嫌弃的沈砚并索要老宅。妹妹如愿嫁给教师却因未婚先孕遭婆家轻视。林晚禾凭借前世记忆与才华，与沈砚携手创业，最终打造知名服装品牌，实现人生逆转。

双胞胎姐妹陈玥与陈思思的暖心故事。姐姐陈玥突发重型再生障碍性贫血、生命垂危，同卵双胞胎妹妹陈思思成为唯一全相合捐献者。面对救亲姐与备孕的两难，陈思思毅然选择捐献造血干细胞。两家人从最初顾虑生育、反复拉扯，到最终彼此共情、全力扶持，共同渡过术前波折与移植难关。

暴雨夜双胞胎姐妹小满与念念不幸被抱错。九岁的小满在养祖母去世后被舅妈赶出家门，情急之下，她借用车站寻人启事上念念的身份前去认亲。DNA检测曝光错换真相，当年的护士记录佐证整件往事。两个女孩一边牵挂各自的养育亲人，一边慢慢解开身边的心结，小满摆脱自卑，也分清恩情与人情债务，活出自我。

双生姐妹带着前世遗憾重生回到九十年代。林飒拒绝江湖权斗，开办女子武馆守护女性。苏媚固守强硬的生存方式。重生的秦飞促成和解，众人搜集线索配合执法力量扫除黑恶，姐妹挣脱过往枷锁，拥抱时代机遇开启全新人生。

双生姐妹带着前世遗憾重生回到九十年代。林飒拒绝江湖权斗，开办女子武馆守护女性。苏媚固守强硬的生存方式。重生的秦飞促成和解，众人搜集线索配合执法力量扫除黑恶，姐妹挣脱过往枷锁，拥抱时代机遇开启全新人生。