The trials and adventures of a female doctor in a small Wild West town.

After Sgt. O'Connor is found dead at the bottom of a cliff, everyone fears that Sully died too in the fall. Dr. Mike and friends go looking for Sully. Matthew quits as sheriff. The Dog Soldiers continue raids on the town.

Dr. Mike and the citizens of Colorado Springs look forward to the advantages a train could bring to their small town, but Sully and the Cheyenne fear progress could lead to their demise. While Loren and Jake are creating a false campaign of the town's highlights to lure the railroad developers to the area, Mike and Sully disagree about whether or not they should build their future and their new home in a town undergoing such change. While the engaged couple searches for a compromise, Colleen befriends a Chinese railroad laborer, named Peter, who has encountered hostile discrimination during his stay.

Finally ready to work again after giving birth to her baby, Dr. Mike must lead a rescue party when Sully and Cloud Dancing are among the passengers on a train that has been overtaken by robbers and wrecked. Sully had negotiated Cloud Dancing's release from Army detention, and the two were taking the train to Colorado Springs when a gang of thieves derailed the train in an effort to rob it. Meanwhile, Dr. Mike must again face the prejudice against women doctors when she finds that the townspeople have become used to being treated by young Dr. Andrew Cook who filled in for her while she was on maternity leave. For his part, Andrew has become reluctant to return the practice to Dr. Mike and go back to Boston, as originally agreed.

Dr. Mike and Sully return from their honeymoon and begin unpacking at their new homestead. A Boston banker comes to town and stirs up controversy among the townspeople as the inevitability of progress ensues.

Lahela "Doogie" Kamealoha, a mixed-race 16-year-old girl in modern-day Hawai'i, juggles a budding medical career with life as a teenager. Guiding Lahela (and also complicating things) is her family, including her spitfire Irish mother, who's also her supervisor at the hospital; and her Hawaiian "Local Boy" father, who is struggling to accept that his daughter is no longer his little girl.

Disney+宣布把《天才小医生 Doogie Howser, M.D.》重启，并改变成女主版的《天才女医生 Doogie Kealoha, M.D.》。这部剧由负责过《老爸老妈的浪漫史 How I Met Your Mother》的Kourtney Kang主创，讲述16岁混血儿Doogie Kealoha在夏威夷担当医生。 经常被各美剧提及，Neil Patrick Harris主演的原版FOX剧《天才小医生》播了4季，共97集。Neil Patrick Harris在剧中饰演14岁青少年医生，但在医生的身份外他其实与其他青少年一样得经历感情﹑友谊上的挑战。

该剧展现了当代社会医生与患者、医生与医生之间充满矛盾的关系，讲述了成为医生的两个男女，看尽人生百态后成长，开启人生的爱情故事，并在实现梦想的过程中，始终坚持医德的本心。

Lifelong friends and medical school graduates Mary Stevens and Don Andrews decide to set up office together. While Mary struggles to earn respect because of her gender, Don gets caught up in his ambitions for a bigger life.

産婦人科医の勇作は女医の千里と結婚。写真マニアの勇作は千里のヌードを撮るだけでは飽き足らず、診察室にビデオカメラをひそかに設置して患者の恥態盗撮していた。理佳はどこも悪くないのに度々診察を受けに来る。勇作はその姿を撮るよう千里に頼んだ。二人はそのビデオを見ながらセックスを楽しんだ。そんな中、千里が勇作の妻であることを知り、嫉妬に燃えた理佳は夫婦への復讐を開始し…