Bethany的信仰正遭受挑战，因为她觉得上帝从来都听不到自己的祷告，在丈夫因自己不能生育而离自己而去后，Bethany更是沮丧到了极点。但一天，天使Metatron出现在她的房间里，请求她的帮助。原来Bartlely和Loki这两个堕落凡间的天使正在设法重返天堂，他们正前往新泽西州的某座教堂实施他们的计划，如果他们成功，不仅能重返天堂，而且将证明上帝制造人类是错误的，世界也会因此毁灭。一头雾水的Bethany虽然不知道她要干什么，但还是带着两名刚认识的助手上路了，路上她结识了几个神叨叨的朋友，他们能不能挽救人类的命运呢……

On Sunday, at Vulture Festival, Smith revealed that he was indeed working on a sequel to “Dogma,” and not just that, he sounded very confident that Ben Affleck and Matt Damon would be back to reprise their original roles as fallen angels Bartleby and Loki. “Some people will be like, ‘Don’t f—ing touch it. You’ll ruin it,'” said Smith. “And I’m here to tell you: I will. I’m f—ing tickled. I found a way in.”