卧底特工沈临洲潜伏八年，即将揪出九鼎集团幕后真凶时身份暴露，与集团二把手陈莫坠海后意外灵魂互换。醒来的他被困在仇人身躯里，唯一上线牺牲、身份彻底成谜，还面临集团内斗与追杀。为完成任务、守护听力受损的女儿依依，他以陈莫身份伪装周旋，联手卧底傅东篱追查真相，竟发现幕后黑手竟是昔日上司老周。一场身份错位、亲情羁绊与正邪对决的大戏就此展开，他在黑暗中坚守正义，誓要撕开犯罪网络、重获新生。

特工总部迪亚大厦新增添了一个神秘的保险柜，结果引来了坏小子吉米的注意。他在两名笨蛋手下的协助下，成功将保险柜盗走，还顺带把迪亚大厦弄得七扭八歪。特工局长恼羞成怒，于是命手下去找特工腓力门及其搭档莫特德罗。腓力门是一个混迹于特工界的笨蛋，他不仅令上司十分头疼，还饱受民众的苛责。在接到局长的命令后，腓力门与莫特德罗准备出征，谁知就在此时，当年被腓力门送入监狱的暴徒特龙其母拉斯出狱，他发誓要用拳头给腓力门爆菊。经过一连串的周折，腓力门总算用特工总部开发的神秘药水使这个暴徒变成了温顺的好孩子。 　　与此同时，吉米的罪恶勾当仍在继续……

叶书阳是心玥集团的一名普通保洁员，过着简朴的生活。他的女儿叶希晨是全球第一财阀集团的总裁，但叶书阳对此毫不知情，只以为女儿在国外打工。叶希晨每月给父亲打巨额生活费，但叶书阳从未动用，生活依然简朴。心玥集团总裁谢清玥因债务危机濒临破产，叶书阳挺身而出，用女儿给的银行卡帮助公司渡过难关。但这张卡被误认为是至尊黑卡，引起债主周蜀铭的忌惮。然而，谢清玥的真实身份逐渐浮出水面，她其实是叶书阳失散多年的妻子。

Agents Napoleon Solo and Illya Kuryakin work for a secret intelligence service working under the auspices of the U.N.Their immediate superior is Mr. Waverly.Together they operate out of a secret base beneath the streets of New York City, and accesses through several cover business such as Del Floria's Tailor Shop and the Masque Club.This secret intelligence service is called U.N.C.L.E.United Network Command for Law and Enforcement.

A mysterious U.S. industrialist, Mr. Alexander, steals a new type of nerve gas from the U.S. Army. He leaves behind a small tablet with the number eight on it. Solo and Kuryakin investigate, with the help of Alexander's ex-wife Tracey, who seeks Alexander to sign her final divorce papers. The trio finds Alexander's parents working like slaves at a Greece rock quarry with the number five painted all around. After freeing the parents (and avoiding Alexander's thugs), they travel to a temple where they are captured by Alexander. It turns out Alexander plans to take over an Asian nation, breaking each of the Ten Commandments along the way.

In Berlin, an UNCLE employee is killed just as he is sending a message to Waverly about a security breach. This occurs just before UNCLE's Summit Five conference, when the leaders of UNCLE's five regions meet and new communications codes are activated. Solo is a suspect in the killing and is subjected to an intense interrogation. Solo and Kuryakin must find the real traitor before it's too late.

A school on Long Island has a student body made up of teenaged children of scientists and other prominent people. Thrush is secretly running the facility and programming the students to steal secrets from their parents. Kuryakin acts as a bodyguard for the teenaged daughter of a scientist while Solo infiltrates the school.

东安村钱富贵和马莲儿两家在建房时因宅基地的地界归属闹起来。支书大山子想尽办法化解矛盾，但两家各不相让。在纪委书记开导下，大山子明白了如何解决新农村建设中出现的新问题。

达克斯在少年时因被人“盖帽”而失去了征战篮球的梦想。长大后达克斯好不容易组建了球队，但辛苦培养的明星球员却被死对头挖走。处在人生谷底的达克斯遇见了功成身退的德鲁大叔，感到了久违的希望。达克斯为了夺冠，孤注一掷地说服德鲁大叔重新出山，两人踏上了英雄集结的旅途，找回德鲁大叔以前的队友，欲征战洛克公园街球联赛 。

该片讲述了关于“大叔”们坚不可摧的友情，和勇敢面对生活积极向上的精神。阐述不服老的精神背后这样一群潮牌大叔给予年轻人不论年纪，不论贫富，都要积极向上、乐观面对生活的教育意义。每一个人物的成长，每一次经历产生的改变都激励着我们，不管遇到什么困难，不管生活给我们多大的压力，都要积极面对！老年人是社会的宝贵财富这句话，绝不仅仅是一句表示一下对老年人尊重的客气话。老年人继续作用的形式可以多种多样、不拘一格。也可以给当代所有年轻人树立一个正确的积极的、乐观向上、勇于冒险的榜样！