Sherlock Holmes is a master at solving the most impenetrable mysteries, but he has his work cut out for him on his latest case. As the famed detective investigates an alleged theft, he’s brought face to face with his most devious adversary yet — Professor Moriarty.

When a couple of swindlers hold young Alice Faulkner against her will in order to discover the whereabouts of letters which could spell scandal for the royal family, Sherlock Holmes is on the case.

A dog leads a detective to a robber's hideout and fetches the police.

当母亲在自己十六岁生日那天神秘失踪后，伊诺拉·福尔摩斯向她的哥哥麦考夫和大名鼎鼎的神探夏洛克寻求帮助。但伊诺拉很快意识到，相较于侦破案件，这两…

福尔摩斯以及维多利亚时代的贝克街又要粉墨登场了，福尔摩斯和他的老搭档华生又遇见了一系列的神秘杀人案，纵横在伦敦迷雾中的罪恶再次蠢蠢欲动，随着他…

福尔摩斯因为过分的寂寞，整日注射可卡因，他的好友华生医生强烈反对他这样摧残自己的身体。一天，福尔摩斯接到一封神秘的请帖，邀他去观看苏联芭蕾舞。芭蕾舞演员彼得洛娃，希望和福尔摩斯结合，因为她想要个孩子，还希望孩子父亲的智能与她的资丽能造就个好孩子。福尔摩斯婉言谢绝。几天后，福尔摩斯收到一件奇怪的包裹，里面是在一个被人从泰晤士河中救起的患有健忘症的女人手里找到的，一张写有福尔摩斯住址的纸条。经过调查和推断，福尔摩斯断定这个女人是从比利时来寻找失踪丈夫的卡比列里。福尔摩斯和华生根据线索去海港调查，福尔摩斯哥哥告诉他们，政府正在试验一种新式战舰，而卡比列里是德国派来的间谍。福尔摩斯返回伦敦，和可卡因打起交道来。

该片剧本受阿瑟·柯南·道尔的福尔摩斯系列小说启发，是一部PG-13的喜剧。

破获接手的第一起案件后，伊诺拉·福尔摩斯（米莉·波比·布朗饰）追随著名的哥哥夏洛克（亨利·卡维尔饰）的脚步，开办了自己的侦探事务所，却发现女性职业侦探的生活并不像看上去那么容易。在她不得不接受成年后的冷酷现实，准备关闭事务所时，一个身无分文的不幸女孩为她带来了第一单生意：寻找失踪的妹妹。但事实证明，这个案子比想象的要复杂得多，因为诺拉即将踏入一个危险的新世界 — 从伦敦险恶的工厂和色彩缤纷的音乐厅，到社会最高阶层和贝克街 221B。随着致命阴谋的触发，伊诺拉需要朋友...

Influenced by Guy Ritchie's film, the role of the heroine, Irene Adler, was also expanded on during the show. Her love affair with Sherlock Holmes is one of the series' main storylines. She will be played by actress Lyanka Gryu. Kavun has also said he only plans to use the motives of the original stories, and will recreate the stories almost from scratch. The series will also assume that Watson's descriptions of the crimes have been embellished. Later he will try to adjust reality to his fantasies. As an example, Holmes' famous pipe will be replaced by cigarettes. Unlike most adaptations of Sherlock Holmes, the Sherlock in this adaptation is younger than Dr. Watson by 15 years.