The adventures of 13-year-old, self-centered Anne Boonchuy who is magically transported to the fictitious world of Amphibia, a rural marshland full of frog-people. With the help of an excitable young frog named Sprig, Anne will become a hero and discover the first true friendship of her life.

Anne and her friends fight for their lives as the fate of both worlds hangs in the balance.

Anne's long journey finally comes to an end as the prophecy reaches its full potential.