Once upon a time in Little Italy, a mob widow plots to avenge the death of her husband with the help of the local gypsies. Her vendetta involves supernatural machinations which help to control the fates and destinies of members of the four prominent mafia families: the Moronis, Mancinis, Mascolos, and Assissis.

A former gang member and her young cousin become embroiled in a vendetta between L.A. gangs, as rivals seek revenge for old crimes.