A naïve young girl desperate to fit in with her new boyfriend's tightly knit crew learns that membership may be deadly. Upon arriving at a party with her new boyfriend, Shawn, desperate-to-fit-in newcomer Debbie learns that the friends have formed a mysterious brotherhood nicknamed "The Murder Club." As Debbie accepts her invitation to join the mysterious club, a murderer who seems to take the group's name to heart begins killing off members one by one.

The world is coming to an end. A mysterious drug called Sister Salvation has taken over the country. The drug promises its user the chance to be blasted into the sun to talk to Shylipis, the god worshiped by a new religion. War broke out and the government has been overthrown. During the war the environment was damaged to the point that if people go out during the day the sun cooks them alive. On top of it all, a mysterious plague has been killing millions.