In 18th-century Romania, after spending much of her life in a traveling circus, human-vampire hybrid Rayne escapes and plots to take down her father, Kagan, the evil vampire king. When she's discovered by three vampire hunters, she manages to convince them to spare her life and join her cause. But slaying a vampire as powerful as Kagan will be no easy task.

Rayne, a half-human half-vampire warrior, is in the America's 1880's Wild West to stop the vampired Billy the Kid and his posse of vampire cowboys.

Rayne fights against the Nazis in Europe during World War II, encountering Ekart Brand, a Nazi leader whose target is to inject Adolf Hitler with Rayne's blood in an attempt to transform him into a dhampir and attain immortality.