Follows the harrowing journey of three frontiersmen who set out to seek aid at a desolate Army fort after their handcart company becomes stranded and stricken by disease. Harassed by bandits and a mysterious native figure, with one companion gravely injured, they are stalked by a dark, primal force. As the fort reveals itself to be a cursed and maddening prison, fear and hunger twist the men into something unrecognizable—something monstrous.

Follows the lives of three young doctors fresh from medical school, and embarking on their new careers.