Hope's Peak Academy is a special school, recognized by the government, that was established in order to gather and nurture top-class students who excel in various fields. This school has two courses: The main course, and the preparatory course. Anyone with the money can enter the preparatory course, even if they don't have any special skills. The 77th class of the main course is filled with students who not only have unique abilities, but unique personalities as well. However, the students learned that "Talent isn't the most important thing in life; it's to involve yourself with people and make yourself a better person while making memories." However, little did they know that a mysterious project and discrimination of the courses were happening right under their noses. Hajime Hinata, a boy from the preparatory class who craves for an ability. The fateful meeting he has drives the future of the school into an unimaginable direction.

The Future Foundation is in shambles after the Final Killing Game and the revelation of the true culprit. As a desperate plot arises from one of the survivors to rid the world of despair once and for all, the remaining Future Foundation members must band together to stop this atrocity from taking place. Fortunately, they find themselves with help from a group of unlikely allies as they race against the clock to stop their world from being changed. In this finale to the Hope's Peak storyline of the Danganronpa series, the players in this neverending death game begin to understand the true meaning behind despair, hope, and atonement.

At Hope's Peak Academy, a school full of extraordinarily talented individuals, Nagito Komaeda is an ordinary boy with no special traits or interesting skills to speak of-except for his incredible unluckiness. Just walking to school in the morning leads to a number of unfortunate accidents, which only escalate as the day goes on. Despite this, Komaeda leads a relatively normal life and is satisfied with his modest slice of happiness. But everything changes when a mysterious boy who declares himself the "Destroyer of the World" arrives to shatter this hopeless paradise.