Dharmapuri movie revolves around Sivaram (Vijayakanth) who lives in exile in Rameswaram with his parents, father Meiyappan (Vijaykumar) and mother Sumithra. Meiyappan is a sincere farmer and a head of a village in Dharmapuri.He strongly believes in traditional industry and encourages his fellow people to take up businesses like making clay pots and artifacts instead of selling their lands to large builders in cities, who want their lands for its rich sand soil. To gain confidence among his people, Meiyappan donates his 200 acres of land for the benefit of the village.

Set in the 1960s and 1970s, the story revolves around the mining mafia bubble that takes Pratap Reddy from rags to riches, as he seeks control over Dharmapuri through sheer violence and ruthlessness. The situation, however, changes when Pratap becomes the target of his friends and family.