After losing his wife seven years earlier, the eccentric Dr. John Dolittle, famed doctor and veterinarian of Queen Victoria’s England, hermits himself away behind the high walls of Dolittle Manor with only his menagerie of exotic animals for company. But when the young queen falls gravely ill, a reluctant Dolittle is forced to set sail on an epic adventure to a mythical island in search of a cure, regaining his wit and courage as he crosses old adversaries and discovers wondrous creatures.

Tottori Kenichi is a foul-mouthed but gifted veterinarian nicknamed Dolittle. His catch phrase is 'pet care means business'. He is the director of his animal clinic and rescues not only 'voiceless' pets but also helps their owners, who lack understanding and caution, with their problems and worries. Working with him is animal nurse Tajima Asuka. Hanabishi Masaru is Dolittle's rival, a charismatic vet and director of another animal hospital who has not only an opposite personality but also a different stance towards pet care.

An eleven year old girl can talk to animals. When a thief causes trouble in the local zoo, she comes to the rescue.

Lisa Dolittle sends her daughter to 'Durango', a Dude Ranch, to find herself. While there, she uses her talent to talk to the animals in order to save Durango from being taken over by a neighboring Ranch.