故事设定于虚构的未来，人类散布在银河系中的各个星球，但都从属于银河帝国(Galactic Empire)的统治之下，一位心理史学家却给出一个预言：帝国即将分崩离析，文明将会灰飞烟灭，为了维系人类这个族群，他不得不行动起来。

Ben Stiller, Kristen Wiig, Jack Black, Matt Damon, Sean Penn, Ted Danson, Mary Steenburgen & Kevin Spacey, who comprise the Clinton Foundation's Celebrity Division, sit down to brainstorm ideas for the Clinton Foundation's 10th Anniversary. Everything is going great until they get a call from President William J. Clinton himself.