Jerk follows the life of acclaimed stand up Tim Renkow, who plays a heightened version of himself; an American art school dropout who needs to get a visa to stay in the UK. The only problem is that Tim has cerebral palsy. This means that people judge him… all the time. Although usually they judge him wrongly, because what they don’t realise is that inside that severely disabled, vulnerable body is a bit of an asshole.

An aspiring recording artist, Adam, is burned by a bad relationship experience and decides that if women won't respond to the "nice guy" then he'll be "the jerk." This is wildly successful with meaningless relationships, but when Adam meets and falls for Molly, who doesn't fall for his jerk routine, Adam is forced to reconsider his dating philosophy.

A young Jehovah's Witness believes the ultimate punishment will be inflicted upon him for typical teenage activity. His life is rather grim until infatuation with a friend's older sister opens his eyes.