A deadly airborne virus finds its way into the USA and starts killing off people at an epidemic rate. Col. Sam Daniels' job is to stop the virus spreading from a small town, which must be quarantined, and to prevent an over reaction by the White House.

A State Park Ranger and his wife, grappling with the disappearance of their teenage son, face a mysterious outbreak that threatens not only their relationship, but in the end, their grip on reality.

The Hyodo-gumi boss—part of Tendokai, Japan’s largest yakuza syndicate—has been brutally murdered. Kazuma Washio (Hitoshi Ozawa), the head of the Washio-gumi and Tendokai’s wakagashira (underboss), is convinced that Yoshinari Myojin (Sho Aikawa), a former Tendokai wakagashira-hosa now running Tokyo’s underworld of thugs and mafia, is behind the killing. Around the same time, Tendokai's 5th-generation chairman Katsushige (Hakuryu) orders Washio to secure a woman named Nagi Toyama (Akane Hotta). Washio sets out with his men, Okita (Yasukaze Motomiya) and Date (Hideo Nakano), but they’re ambushed by a group of heavily armed youths. Barely escaping, they manage to bring Nagi to their hideout—only to discover she’s a key player in a power struggle over the Tokyo Casino Project. And so begins the greatest conflict yet, entangling yakuza, mafia, street gangs, the police, and even the state itself—

In the midst of a global epidemic, Annie finds herself the sole carer of her eight-year-old nephew, but he has questions only a mother can answer.

After an infectious outbreak causes people to become rage filled and cannibals, a group of survivors must figure out how to get by. The infected aren't the only threat though. After the fall of society, people begin to lose their humanity, as these three struggle to hold on to theirs.

Higurashi Outbreak is set in the same Hinamizawa village of the previous stories. The village has been completely sealed off due to a mysterious virus in 1983, and Keiichi Maebara and Rena Ryūgū deal with the outbreak. But this time, they don't know if its Oyashiro-sama's curse or a conspiracy. It is also shown that Rika might be infected by the virus. Not much is known about the story yet, but in an interview the makers of the OVA revealed that the ending will differ from the original story.