Young medical professional couple set out to prove that gender is not a factor in the ability to do a job well. Hilarity ensues as they swap jobs, clothes, and gender, in order to see what life is like from a different perspective.

Hwang Tae Hee leads a charmed life, and after growing up in a wealthy family, she easily attains a coveted job. Too much of a workaholic to make time for romance, she is taken aback when she falls hard for Bong Joon Soo. She pursues him and they soon get married, but when the honeymoon is over, Tae Hee finds that her rival at work and husband's ex, Baek Yeo Jin, has taken over her job. As she struggles with her job and marriage, she must also cope with the attention of her arrogant, immature boss, Goo Yong Shik, who falls for her as her life falls to pieces. Queen of Reversals is an empowering tale of a woman who manages to regain everything she's lost through sheer willpower and determination.