Two naive slackers, Sam and Alex, are hired to transport a box of contraband psychedelic toads from LA to Vegas. When the desert heat causes the toads to suffer heatstroke, our two heroes are inadvertently dosed when they give the toads CPR and suddenly find themselves on a hallucinogenic odyssey.

Toad's life is just one big adventure! His latest and greatest hobby is racing around the countryside in his new motor car getting into all sorts of trouble. Meanwhile, his wonderful home, Toad Hall, has been taken over by the wicked weasels and ferrets. It's now up to Toad and his riverbank friends to embark on the biggest adventure of all - the Great Battle of Toad Hall!

During a stagnant moment in her marriage, Kay orchestrates an evening away from family responsibilities to pursue a surprising liaison.