小敏和小雅曾因争抢渣男阿哲反目成仇，却在租房时阴差阳错成为合租室友。情敌同居的日子里，过往的芥蒂加上生活习惯的差异，让两人摩擦不断、形同陌路，客厅里的空气都带着火药味。直到小敏突然感冒，高烧不退，向来针锋相对的小雅却放下隔阂，连夜悉心照料。这场意外打破了僵局，两人在谈心时发现彼此都是阿哲感情骗局的受害者。最终，她们携手收集证据，当众揭穿了阿哲的渣男真面目，彻底摆脱情感枷锁，从情敌变成挚友，一起奔赴自由美好的新生活。

為了挽救家人老式西服店的客源，來自台南的陳凱南考上台北的服裝設計系，以為撿到便宜的合租房，原來是同志按摩師房東兼同校學弟李斯豪找分母省錢的陰謀！除此之外，另一位同居室友是本來就跟家人不合盤，白天是恐怖小說家，晚上是跨性別調酒師及變裝皇后，有著多重身分的Rose。三個北漂的合租室友各自面對各自的感情煩惱⋯

為了挽救家人老式西服店的客源，來自台南的陳凱南考上台北的服裝設計系，以為撿到便宜的合租房，原來是同志按摩師房東兼同校學弟李斯豪找分母省錢的陰謀！除此之外，另一位同居室友是本來就跟家人不合盤，白天是恐怖小說家，晚上是跨性別調酒師及變裝皇后，有著多重身分的Rose。三個北漂的合租室友各自面對各自的感情煩惱⋯

首富千金白果为备考与室友王婉瑜合租，隐藏身份的她遭王婉瑜霸凌诬陷，王婉瑜撕毁其母遗照、抢奢侈品还造谣羞辱，白果一直忍让。王婉瑜男友、白家特助顾闻揭穿白果身份，王婉瑜被学校开除且全行业封杀。为报复，王婉瑜勾结高利贷头目羞辱白果与未婚夫陆砚深，陆砚深身份随后曝光，王婉瑜所在的龙飞公司破产，她还惨遭毁容。绝境中，王婉瑜与龙飞绑架白果索要十亿赎金，虐打陆砚深。白果触发父亲装的报警系统，白山海赶来，龙飞团伙覆灭，王婉瑜入狱。白果与陆砚深历经磨难后结婚，合租风波告终，白果和康复的朋友入职白氏集团 。

首富千金白果为备考隐藏身份与室友合租，却遭虚荣贪婪的舍友王婉瑜霸凌，被诬陷“被包养”。白果屡次忍让，但王婉瑜变本加厉：撕毁其母遗照、抢走奢侈品、造谣羞辱。白果忍让未暴露身份，直至王婉瑜男友顾闻（白家特助）揭穿真相，王婉瑜遭学校开除、全行业封杀。为报复，王婉瑜勾结高利贷头目，对白果和未婚夫陆砚深百般羞辱，最终陆砚深身份曝光，龙飞公司破产，王婉瑜毁容，王婉瑜走投无路，与龙飞合伙绑架白果索要十亿赎金，并虐打其未婚夫陆砚深。危急时刻，白果触发父亲安装的报警系统，...

On a rainy night in 1928 in a Pennsylvania factory town called Iverstown, Martha Ivers (Janis Wilson), thirteen years old, is trying to escape from the guardianship of her wealthy, domineering aunt. Her friend, the street-smart, poor Sam Masterson (Darryl Hickman), comes for her through her bedroom window, but Martha's aunt catches them. While Sam slips out unnoticed, Martha hits Mrs. Ivers on the head, causing her to fall down the long staircase and die. Though Sam saw nothing, the event was witnessed by Walter O'Neil (Mickey Kuhn), the son of Martha's tutor (Roman Bohnen), known as Mr. O'Neil. Martha lies about the incident to Mr. O'Neil, and Walter supports her.[5] 　　Mr. O'Neil suspects what happened but presents Martha's version of events to the police, that an intruder is responsible; he makes use of his knowledge by having her marry his son. When the police identify a former employee of the aunt as the murderer, the two O'Neils and Martha help convict him; he is punished by hanging.[5] 　　Eighteen years later, the older O'Neil has died. Walter (now played by Kirk Douglas) is the district attorney, while Martha (Barbara Stanwyck) has used her inheritance from her aunt to build a large business empire. Their marriage is one-sided; he loves her, but she does not love him. 　　Sam (Van Heflin), now a drifter and gambler, stops in the small town by chance to have his car repaired after an accident. While waiting for repairs, at his old home, now a boarding house, he meets Antonia "Toni" Marachek (Lizabeth Scott), who has just been released from jail. She is later picked up for violating her probation by not returning to her hometown. Sam goes to see Walter, to see if he can use his influence to get her released. 　　Walter is convinced Sam has returned with blackmail in mind, giving Walter a motive to run Sam out of town. When Martha reacts with joy to the news of Sam's return, Walter's jealousy provides an additional motive. Walter forces Toni to set Sam up. Sam is beaten and driven out of town, but he is too tough to be intimidated. When all else fails, Walter makes a half-hearted attempt to kill Sam himself, but is easily disarmed. Martha then inadvertently blurts out the couple's fears of blackmail, which prove to be groundless: Sam says he did not witness the death. Martha breaks down and laments that he left without her all those years ago, taking with him her only chance for love and freedom. 　　Sam is torn between his old love and his new. Although he eventually forgives Toni for betraying him, he and Martha spend an idyllic day together, rekindling his feelings for her. 　　Walter arranges to meet Sam to finally settle matters. Before Sam arrives, Walter gets drunk and Martha finds out about the meeting. When Walter falls down the stairs and is knocked unconscious, Martha urges Sam to kill him. Sam instead brings Walter around. Martha pulls out a gun and threatens to shoot Sam in "self defense" as an intruder. However, Sam gambles that Walter will not back up her story; he turns his back on her and leaves. 　　Walter embraces and kisses his wife; then he points the gun at her midriff. Oddly relieved, she puts her hand over his hand on the trigger and presses. As she is dying, she defiantly states her name is not Martha Ivers, but Martha Smith. Outside, Sam hears the shot. He runs back toward the mansion, but sees Walter, holding Martha's body, shoot himself. Sam and Toni drive away together.

On a rainy night in 1928 in a Pennsylvania factory town called Iverstown, Martha Ivers (Janis Wilson), thirteen years old, is trying to escape from the guardianship of her wealthy, domineering aunt. Her friend, the street-smart, poor Sam Masterson (Darryl Hickman), comes for her through her bedroom window, but Martha's aunt catches them. While Sam slips out unnoticed, Martha hits Mrs. Ivers on the head, causing her to fall down the long staircase and die. Though Sam saw nothing, the event was witnessed by Walter O'Neil (Mickey Kuhn), the son of Martha's tutor (Roman Bohnen), known as Mr. O'Neil. Martha lies about the incident to Mr. O'Neil, and Walter supports her.[5] 　　Mr. O'Neil suspects what happened but presents Martha's version of events to the police, that an intruder is responsible; he makes use of his knowledge by having her marry his son. When the police identify a former employee of the aunt as the murderer, the two O'Neils and Martha help convict him; he is punished by hanging.[5] 　　Eighteen years later, the older O'Neil has died. Walter (now played by Kirk Douglas) is the district attorney, while Martha (Barbara Stanwyck) has used her inheritance from her aunt to build a large business empire. Their marriage is one-sided; he loves her, but she does not love him. 　　Sam (Van Heflin), now a drifter and gambler, stops in the small town by chance to have his car repaired after an accident. While waiting for repairs, at his old home, now a boarding house, he meets Antonia "Toni" Marachek (Lizabeth Scott), who has just been released from jail. She is later picked up for violating her probation by not returning to her hometown. Sam goes to see Walter, to see if he can use his influence to get her released. 　　Walter is convinced Sam has returned with blackmail in mind, giving Walter a motive to run Sam out of town. When Martha reacts with joy to the news of Sam's return, Walter's jealousy provides an additional motive. Walter forces Toni to set Sam up. Sam is beaten and driven out of town, but he is too tough to be intimidated. When all else fails, Walter makes a half-hearted attempt to kill Sam himself, but is easily disarmed. Martha then inadvertently blurts out the couple's fears of blackmail, which prove to be groundless: Sam says he did not witness the death. Martha breaks down and laments that he left without her all those years ago, taking with him her only chance for love and freedom. 　　Sam is torn between his old love and his new. Although he eventually forgives Toni for betraying him, he and Martha spend an idyllic day together, rekindling his feelings for her. 　　Walter arranges to meet Sam to finally settle matters. Before Sam arrives, Walter gets drunk and Martha finds out about the meeting. When Walter falls down the stairs and is knocked unconscious, Martha urges Sam to kill him. Sam instead brings Walter around. Martha pulls out a gun and threatens to shoot Sam in "self defense" as an intruder. However, Sam gambles that Walter will not back up her story; he turns his back on her and leaves. 　　Walter embraces and kisses his wife; then he points the gun at her midriff. Oddly relieved, she puts her hand over his hand on the trigger and presses. As she is dying, she defiantly states her name is not Martha Ivers, but Martha Smith. Outside, Sam hears the shot. He runs back toward the mansion, but sees Walter, holding Martha's body, shoot himself. Sam and Toni drive away together.

讲述一群在大城市合租的90后年轻男女，他们性格迥异，不同的工作环境下面临着不同的人情世故。这些不同的三观融合在一间几十平米的合租房内，从而产生有趣却蕴含生活哲理的良性反应，面对屡屡发生在周遭的突发事件，他们更多用自己的调侃与吐槽，一笑而过。《难搞的室友》希望通过展现室友之间发生的奇葩、有趣的故事，将大城市中的合租生活通过节目把影响力放大，让更多类似经历的人群在节目中找到共鸣，找到自己。在用户分享故事本身的喜悦同时，激发并鼓励大家去终结孤单、拥抱生活。和有趣的人一起做有趣的事，房子是租来的，但生活不是。