Dr. Nathaniel Grant is a pioneering organ-transplant surgeon who takes risks that other doctors would not in order to save the lives of his patients. He works closely with his ex-wife, Kate Armstrong, an organ-donor coordinator with whom he has a volatile relationship. Grant's arrogance and willingness to perform risky procedures causes him to butt heads with the hospital administration. But his main focus is on his intense relationship with his job and his patients, often at the expense of his family.

伊恩来到一家里斯本的诊所做老师，向有视觉障碍的盲童父母传授导航技巧。这家诊所的国际社区对伊恩的非传统教学法有怀疑有期待。对伊恩来说，定位首先从大脑和想象力开始，然后伴随着感官知觉。尽管他的方法有效，但不免有些风险。