Follow the misadventures of 11-year-old Joe Connolly and his three best friends in their first year at O’Malley Middle School.

Young Reinaldo is fascinated by flamboyance, but his mother has been the main influence of machismo in their Latino household. When we see Reinaldo as an adult, his mother persists on having a straight son attend an upcoming wedding, which causes much of his distraction at work. That is until he interviews Claire, a candidate whose valuable professional experience goes unnoticed by Reinaldo until she strikes him as a great candidate to get things done in the office. More importantly for Reinaldo, she's a way to fulfill his mother's demand for him to attend an old family friend's wedding with a woman.

沈宇宙（李圣经 饰）的爸爸意外去世后，被爸爸的情妇卖了房子，一夕间失去所有，决心要向情妇的儿子韩冬辰（金英光 饰）报复，夺回属于自己的一切。但当宇宙越靠近冬辰，就愈发现他令人心疼的一面。

沈宇宙（李圣经 饰）的爸爸意外去世后，被爸爸的情妇卖了房子，一夕间失去所有，决心要向情妇的儿子韩冬辰（金英光 饰）报复，夺回属于自己的一切。但当宇宙越靠近冬辰，就愈发现他令人心疼的一面。

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固执己见的爸爸阿北，和调皮捣蛋的儿子至尊宝，以及古灵精怪的狗狗大哈搞笑碰撞的家庭喜剧，欢乐时刻都在这个小家庭上演......

在这间堂上综合医院医院里，每个医生都是牛鬼蛇神。玩股票、上酒店、整天打电动。他们只在乎自己，弃病人於不顾。直到最强名医的出现，让医院开始产生变化；他的精湛医术，更令人大开眼界、为之慑服。他要和病患站在同一阵线，对抗无情腐败的医界。外科医师相良浩介，拥有精湛的医术，总是笑脸迎人，深受病患的欢迎。在院长邀约下，他来到了经营困难的“堂上综合医院”，这里的医师早已忘记救人初衷、整天沉迷享乐。上任第一天，相良到手术室参观，当时大家公认的医院继承人森山正在执刀。未料病患突发状况，医疗团队一阵慌乱，相良立刻下达指示。

外表风光无限的堂上综合医院，实际上正经历着经营等方面的困境。在这里，本应“救死扶伤”的医生们似乎忘记了自己的职责与医德，醉心名利，惮于担当，明哲保身，如是弊端重重，正将这家医院推向万劫不复的深渊。这一天，名叫相良浩介（泽村一树 饰）来到此地。他是曾在大学医院供职十余年、有着三千次开刀经历的外科医师，丰富的从艺经验、阳光向上的开朗性格加上崇高无上的医德，让他成为广大患者的福音。泽村精湛的医术很快一起医院内外的关注，而以森山卓（高岛政伸 饰）医生为首的一众“寄生虫”则视其为眼中钉。 　　白衣天使的明争暗斗，关乎荣誉与私利的对决……