故事发生在22世纪的新伦敦，新苏格兰场的贝丝·雷斯垂德探长在追捕畸形怪异的法国流氓遗传学家马丁·芬威克时，发现他的同伴正是19世纪的犯罪大师詹姆斯·莫里亚蒂教授（这不是莫里亚蒂的原型，实际上是他的克隆体，由福尔摩斯埋在瑞士冰洞里的尸体上的细胞制造而成）。著名生物学家埃文·哈格里夫斯爵士（长相酷似道尔）刚刚发明了细胞再生术。贝丝知道福尔摩斯活了下来，而且真的活到了耄耋之年，她还知道福尔摩斯的尸体被保存在新苏格兰场地下室的一个玻璃壁、装满蜂蜜的棺材里（这可能既是指亚历山大大帝的尸体被保存在蜂蜜中不会腐烂的传说，也是指道尔在原著中所说的福尔摩斯退休后成为养蜂人的事实）。她从地下室取出尸体，交给埃文爵士。然后，这位生物学家利用他的细胞再生技术，让福尔摩斯的身体重新焕发生机和青春，从而让这位侦探能够与莫里亚蒂进行战斗。 作为雷斯垂德探长的后代，贝丝继承了华生医生的日记。当她让她的执法机器人阅读这些日志以获取有关福尔摩斯的信息时，机器人最终模仿了好医生的个性。福尔摩斯最终也找回了他在贝克街的老房间。

当夏洛克·福尔摩斯坠入莱辛巴赫瀑布时，一次自然的时空扭曲将他传送到了2249年。在那里，他被位于哈雷街医院的里吉利亚医生Wt'sn治好。很快，他们与福尔摩斯的曾曾侄孙女、警探麦考夫·福尔摩斯联手。他接到的第一个案子是由警长布雷斯塔尔委托的，警长正在寻找一个名叫弗莱德的失踪外星男孩。

When a couple of swindlers hold young Alice Faulkner against her will in order to discover the whereabouts of letters which could spell scandal for the royal family, Sherlock Holmes is on the case.

Sherlock Holmes is a master at solving the most impenetrable mysteries, but he has his work cut out for him on his latest case. As the famed detective investigates an alleged theft, he’s brought face to face with his most devious adversary yet — Professor Moriarty.

Sherlock Holmes (1932) is a film starring Clive Brook as the eponymous London detective. The movie is based on the successful stage play by William Gillette, in turn based on the stories by Arthur Conan Doyle, and is directed by William K. Howard for the Fox Film Corporation.

福尔摩斯和沃森调查一个科学怪人的犯罪线索，这个科学怪人似乎是在制造某些可怕的生物。

福尔摩斯和华生正在追踪一名犯罪兼科学奇才，此人似乎能操控一些令人难以置信的怪物和造物。

描述英国神探福尔摩斯的傻瓜弟弟，因为鸿福齐天，使他幸运地周旋在一个伪装的歌剧女星和一个无所不在的教授之间，从而破获了一宗神秘的国际间谍案。

Sherlock Holmes (Anthony Higgins) is awakened in modern times with a tale that he had invented a method of suspended animation that he had utilized on himself. Awakened by an earthquake, he is helped by Amy Winslow, who lives at 1994 Baker Street in San Francisco. There he is joined by a new group of Baker Street Irregulars led by Zapper. His battles lead him to the evil Moriarty clan led by James Moriarty Booth.