继女的未婚夫在一次蹦极事故中丧生，继女的婚礼也因此变得悲惨。

After a four month absence, Sherlock Holmes returns to Baker Street following several attempts on his life. Holmes had been away on an important assignment for the French government - recovering the Mona Lisa that had bee stolen from the Louvre. He was successful in his task and appropriately rewarded by the French but he raised the ire of the crime's perpetrator - Professor Moriarty. On the morning of his return, the Professor visited Holmes in his flat and warned him to cease or he would have no choice but to take extreme measures. With several attempts on his life having already taken place, Holmes and Watson head for Switzerland. Moriarty is a relentless pursuer however and he and Holmes have a fateful encounter at the Reichenbach Falls. Written by garykmcd

黑斯廷斯上尉应波洛之邀，在事隔多年后回到了现已是乡间旅馆的斯泰尔斯庄园——这对老朋友初次相遇并共同经历第一桩谋杀案件的地方。然而，令满心憧憬着与波洛及女儿朱迪斯相聚的上尉始料未及的是，比上次更加凶险的谋杀正等待着他的到来。原来，波洛追寻一个手法高超的谋杀犯来到此地，希望阻止罪行的发生。身体每况愈下的他要求黑斯廷斯的协助。但波洛拒绝透露凶手，只断定凶手就是旅馆中的某一个人……

黑斯廷斯上尉应波洛之邀，在事隔多年后回到了现已是乡间旅馆的斯泰尔斯庄园——这对老朋友初次相遇并共同经历第一桩谋杀案件的地方。然而，令满心憧憬着…

艾德里安·蒙克（阿蒙）曾是旧金山警局侦探，他具有对事物观察细致入微、过目不忘的天赋和高超的破案头脑，他以独特的破案方法破获不少棘手案件，是有名的侦探。几年前阿蒙深爱的妻子被炸弹意外炸死，巨大的打击使他患上了一种强迫症——异常洁癖，极度不能容忍杂乱肮脏无序的环境，畏高，对许多微生物心理过敏，害怕人群……这些奇怪的症状让他无法再胜任警队的职务，他在护士（后来成为了他的助手）沙伦娜的协助下，开设了私人侦探所。两人就像神经版的福尔摩斯和女性版的华生医生，和探长斯塔迈尔以及副手兰迪继续侦破种种奇异的案件，同时，蒙克下决心要找到杀死他妻子的凶手……

Former police detective Adrian Monk (Tony Shalhoub), whose photographic memory and amazing ability to piece together tiny clues made him a local legend, has suffered from intensified obsessive-compulsive disorder and a variety of phobias since the unsolved murder of his wife, Trudy, in 1997. Now on psychiatric leave from the San Francisco Police Department and working as a freelance detective/ consultant on difficult cases, Monk hopes to convince his former boss, Captain Leland Stottlemeyer (Ted Levine), to allow him to return to the force. Stottlemeyer, who wavered between admiration for Monk and annoyance at his eccentricities during the first season, is becoming more of a friend to Monk as the series develops, frequently calling him in to help, as much for Monk's benefit as for his own. However, he knows Monk's limitations as well as his strengths and may still harbor doubts about the wisdom of allowing Monk to carry a gun or subdue a perpetrator. Stottlemeyer's second-in-command, Lieutenant Randall Disher (Jason Gray-Stanford), also seems to be developing both admiration and compassion for the man he once labeled "the defective detective." 　　Despite flaws and inadequacies all around, the three are becoming an increasingly effective team, with additional help from Monk's personal assistant. From the double-episode pilot through the first half of season three, Monk was aided by his nurse, Sharona Fleming (Bitty Schram). But in the tenth episode of the third season, Sharona was replaced by a new assistant, Natalie Teeger (Traylor Howard). Like Sharona, a divorcee with a son named Benjy, Natalie is a single parent, a widow with a daughter named Julie (Emmy Clarke). Unlike Sharona, Natalie is not a nurse but a former bartender with a fresh perspective on "Mr. Monk," as she still addresses her new boss.